Copy number variations burden on miRNA genes reveals layers of complexities involved in the regulation of pathways and phenotypic expression.
oleh: Avinash M Veerappa, Megha N Murthy, Sangeetha Vishweswaraiah, Kusuma Lingaiah, Raviraj V Suresh, Somanna Ajjamada Nachappa, Nelchi Prashali, Sangeetha Nuggehalli Yadav, Manjula Arsikere Srikanta, Dinesh S Manjegowda, Keshava B Seshachalam, Nallur B Ramachandra
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2014-01-01 |
Deskripsi
MicroRNAs are involved in post-transcriptional down-regulation of gene expression. Variations in miRNA genes can severely affect downstream-regulated genes and their pathways. However, population-specific burden of CNVs on miRNA genes and the complexities created towards the phenotype is not known. From a total of 44109 CNVs investigated from 1715 individuals across 12 populations using high-throughput arrays, 4007 miRNA-CNVs (∼ 9%) consisting 6542 (∼ 5%) miRNA genes with a total of 333 (∼ 5%) singleton miRNA genes were identified. We found miRNA-CNVs across the genomes of individuals showing multiple hits in many targets, co-regulated under the same pathway. This study proposes four mechanisms unraveling the many complexities in miRNA genes, targets and co-regulated miRNA genes towards establishment of phenotypic diversity.