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The use of medicinal plants for cure, treatment and control of diseases is one of the ancient forms of medical practice in mankind history. The 80% population of underdeveloped nations is still dependent on traditional medicinal remedy for its basic medical needs. Malva neglecta Wallr. is a medicinal plant used for phytotherapy for the treatment of cough, respiratory and digestive problems. The present study was conducted for the identification of pharmacological activity of crude extract of Malva neglecta Wallr. on inflammatory, emesis, and analgesic effect in different In-Vivo moels. For this study we performed hind paw, eddy hot plate, and check emesis methods. In the standard condition methods, 78.05%, 76.75% inhibition in anti-emetic, anti- inflammatory and in analgesic it shows significant effect. Malva neglecta Wallr. crude extract (Mn.Cr) possess anti-inflammatory, analgesic and antiemetic activities.