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This paper proposes a hybrid optimization method based on the fusion of the Simulated Annealing (SA) and Clonal Selection Algorithm (CSA), in which the SA is embedded in the CSA to enhance its search capability. The novel optimization algorithm is also employed to deal with several nonlinear benchmark functions as well as a practical engineering design problem. Simulation results demonstrate the remarkable advantages of our approach in achiev- ing the diverse optimal solutions and improved convergence speed.