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For many cancer control programs, cancer navigation has emerged as a specific strategy to improve access to supportive care and the patients’ experience of cancer care. This study contributes to a better understanding of professional navigation by comparing two Canadian models: Quebec’s Pivot Nurse in Oncology (PNO) and Nova Scotia’s Cancer Patient Navigator (CPN). Qualitative interviews were conducted with professional navigators, patients and family members, front-line staff, physicians and health administrators (interviews: n=49; focus groups: n=10). The two models were analyzed using the professional navigation framework (Fillion et al., 2012). Although the models are different, results show that professional navigators in both programs perform similar functions and face similar challenges. This study highlights the complexity and the value of cancer navigation and recommends relevant actions to optimize its management within the health care system.