Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity
oleh: Yiwei Shen, Kamala Vanarsa, Zhihua Yin, Zhihua Yin, Ting Zhang, Ting Zhang, Jessica Castillo, Min Dai, Linghua Zou, Linghua Zou, Ling Qin, Jieying Wang, Qiang Guo, Ramesh Saxena, Michelle Petri, Nan Shen, Nan Shen, Nan Shen, Nan Shen, Nan Shen, Zhizhong Ye, Zhizhong Ye, Chandra Mohan, Huihua Ding
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2023-08-01 |
Deskripsi
ObjectiveThere is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.MethodsuL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and a US cohort (n=219) of SLE patients and controls using ELISA. A longitudinal cohort includes 20 active Chinese LN patients.ResultsuL-selectin was significantly increased in active LN patients compared to active non-renal SLE, inactive LN, inactive non-renal SLE, chronic kidney disease patients, and healthy controls. uL-selectin positively correlated with global and renal disease activities and was significantly associated with histological activity index and chronicity index (CI). Low uL-selectin was an independent predictor for high CI. During follow-up, uL-selectin levels decreased significantly in the complete renal remission group.ConclusionuL-selectin is a novel biomarker of disease activity and renal histopathology in LN across multiple ethnicities. It also reflects treatment response in LN patients during follow up.