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Abstract In this paper, we study a class of predator-prey model with Holling-II functional response. Firstly, by using linearization method, we prove the stability of nonnegative equilibrium points. Secondly, we obtain the existence, direction, and stability of Hopf bifurcation by using Poincare–Andronov Hopf bifurcation theorem. Finally, we demonstrate the validity of our results by numerical simulation.