Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer.
oleh: Florent Tixier, Ashley M Groves, Vicky Goh, Mathieu Hatt, Pierre Ingrand, Catherine Cheze Le Rest, Dimitris Visvikis
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2014-01-01 |
Deskripsi
<h4>Methods</h4>Thirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis.<h4>Results</h4>Blood flow visualization provided by DCE-CT images was significantly correlated with 18F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-value<0.02).<h4>Conclusion</h4>The positive correlation found with tumor blood flow indicates that intra-tumor heterogeneity of 18F-FDG PET accumulation reflects to some extent tracer distribution and consequently indicates that 18F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization.