Design and Optimization of a Natural Medicine from <i>Copaifera reticulata</i> Ducke for Skin Wound Care

oleh: Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Gonçalves, Jéssica Bassi da Silva, Flávia Amanda Pedroso de Morais, Rafaela Said dos Santos, Bruno Henrique Vilsinski, Gabrielly Lorraynny Martins de Oliveira, Magali Soares dos Santos Pozza, Marcos Luciano Bruschi, Bruna Barnei Saraiva, Celso Vataru Nakamura, Wilker Caetano

Format: Article
Diterbitkan: MDPI AG 2022-10-01

Deskripsi

In this study, we developed a bioadhesive emulsion-filled gel containing a high amount of <i>Copaifera reticulata</i> Ducke oil-resin as a veterinary or human clinical proposal. The phytotherapeutic system had easy preparation, low cost, satisfactory healing ability, and fly repellency, making it a cost-effective clinical strategy for wound care and myiasis prevention. Mechanical, rheological, morphological, and physical stability assessments were performed. The results highlight the crosslinked nature of the gelling agent, with three-dimensional channel networks stabilizing the <i>Copaifera reticulata</i> Ducke oil-resin (CrD-Ore). The emulgel presented antimicrobial activity, satisfactory adhesion, hardness, cohesiveness, and viscosity profiles, ensuring the easy spreading of the formulation. Considering dermatological application, the oscillatory responses showed a viscoelastic performance that ensures emulgel retention at the action site, reducing the dosage frequencies. <i>In Vivo</i> evaluations were performed using a case report to treat ulcerative skin wounds aggravated by myiasis in calves and heifers, which demonstrated healing, anti-inflammatory, and repellent performance for the emulsion-filled gel. The emulgel preparation, which is low in cost, shows promise as a drug for wound therapy.