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Genetic factors are found to play a major role in male infertility. Inf act, it has been suggested that a linear correlation exists between seminal defects and chromosomal abnormalities. Carriers of various mutations are at an increased risk of infertility, spontaneous abortions and chromosomally abnormal offsprings. Chromosomal screening, followed by detailed genetic counselling is highly recommended in all cases of Azoospermia and Severe Oligospermia.