Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization

oleh: Jian K. Liu, Helene M. Schreyer, Arno Onken, Fernando Rozenblit, Mohammad H. Khani, Vidhyasankar Krishnamoorthy, Stefano Panzeri, Tim Gollisch

Format: Article
Diterbitkan: Nature Portfolio 2017-07-01

Deskripsi

How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.