Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo
oleh: Richard T. O’Neil, Sunandan Saha, Ruth Ann Veach, Richard C. Welch, Lauren E. Woodard, Cliona M. Rooney, Matthew H. Wilson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-04-01 |
Deskripsi
Delivery of therapeutic proteins to patients may be costly to administer, and often requires repeated injections. Here, the authors use antigen-specific T cells expressing erythropoietin, and show that following transfer in mice, cell expansion and erythropoietin production can be boosted by vaccination, raising the haematocrit.