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This paper presents a comprehensive survey of the generalization of hybrid numbers and hybrid polynomials, particularly in the fields of mathematics and physics. In this paper, by using higher-order generalized Fibonacci polynomials, we introduce higher-order generalized Fibonacci hybrid polynomials called higher-order generalized Fibonacci hybrinomials. We obtain some special cases and algebraic properties of the higher-order generalized Fibonacci hybrinomials, such as the recurrence relation, generating function, exponential generating function, Binet formula, Vajda’s identity, Catalan’s identity, Cassini’s identity and d’Ocagne’s identity. We also present three different matrices whose components are higher-order generalized Fibonacci hybrinomials, higher-order generalized Fibonacci polynomials and Lucas polynomials. By using these matrices, we obtain some identities related to these newly established hybrinomials.