Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome
oleh: Emily V. Dutrow, Deena Emera, Kristina Yim, Severin Uebbing, Acadia A. Kocher, Martina Krenzer, Timothy Nottoli, Daniel B. Burkhardt, Smita Krishnaswamy, Angeliki Louvi, James P. Noonan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Human Accelerated Regions (HARs) are prime candidates for driving the evolution of uniquely human traits. Using humanized mice, the authors show how one HAR alters gene expression during embryonic development, yielding insight into HAR function.