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Introduction: Pain control in patients undergoing orthodontic treatment is one of the major challenges of such treatments. The use of new technologies such as Laser offers promising results in this field. The goal of this study is to survey the works on effect of low-power laser on pain relief during orthodontic treatments. Materials and Methods: The key terms including “orthodontics, reduction, pain, low level, power, laser and laser therapy” alone as well as combinations. Those key terms were used to search the databases including “Google Scholar, Science Direct, and PubMed”. The review of collected sources was done which led to selection of 557 papers. The validation was done through CONSORT guidelines. Results: After review of selected papers, 34 studies including 32 human studies and 2 animal studies were selected. Conclusion: The positive findings of reviewed studies on use of laser therapy suggest that low power laser could be effective on pain relief. Conducting further studies on this subject will be beneficial. Keywords: Orthodontics; Pain; Review; Low-power; Laser.