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The Norwegian Mother and Child Cohort Study (MoBa) is an observational, prospective study of up to 100 000 families. The study aims to find causes of diseases, with a focus on the interplay between early exposures and genetic factors. The collection of possible exposures starts in pregnancy. As of September 2007, about 80 000 families participate. A series of subprojects are ongoing, and analyses and publications are on their way. This paper presents the present situation of MoBa, and highlights new challenges and opportunities.