Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
oleh: Yin-Di Su, Tung-Ying Wu, Zhi-Hong Wen, Ching-Chyuan Su, Yu-Hsin Chen, Yu-Chia Chang, Yang-Chang Wu, Jyh-Horng Sheu, Ping-Jyun Sung
| Format: | Article |
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| Diterbitkan: | MDPI AG 2015-12-01 |
Deskripsi
Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (1–5), were isolated from the octocoral Briareum sp. The structures of briaranes 1–5 were elucidated by spectroscopic methods. Briarenolides U–Y (1–5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.