One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction
oleh: Bo Yang, Chuanye Tao, Taofeng Shao, Jianxian Gong, Chao Che
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2016-07-01 |
Deskripsi
A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides. The three-component coupling proceeds through the Groebke–Blackburn–Bienaymé reaction followed by a retro-aza-ene reaction and subsequent nucleophilic reaction of the in-situ generated imidazo[1,2-a]pyridines bearing an isocyanate functional group.