miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage
oleh: David W. Salzman, Kotoka Nakamura, Sunitha Nallur, Michelle T. Dookwah, Chanatip Metheetrairut, Frank J. Slack, Joanne B. Weidhaas
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-03-01 |
Deskripsi
MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation.