γ-Selective C(sp3)–H amination via controlled migratory hydroamination

oleh: Changseok Lee, Huiyeong Seo, Jinwon Jeon, Sungwoo Hong

Format: Article
Diterbitkan: Nature Portfolio 2021-09-01

Deskripsi

Sequential alkene isomerization and cross-coupling enables remote functionalization, but coupling has been limited to positions at a carbon chain terminus or proximal to a functional group. Here the authors show a method to interrupt isomerization with a nickellacycle, which enables coupling at an atypical, unreactive position.