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γ-Selective C(sp3)–H amination via controlled migratory hydroamination
oleh: Changseok Lee, Huiyeong Seo, Jinwon Jeon, Sungwoo Hong
Format: | Article |
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Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Sequential alkene isomerization and cross-coupling enables remote functionalization, but coupling has been limited to positions at a carbon chain terminus or proximal to a functional group. Here the authors show a method to interrupt isomerization with a nickellacycle, which enables coupling at an atypical, unreactive position.