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Structural basis for transcription initiation by bacterial ECF σ factors
oleh: Lingting Li, Chengli Fang, Ningning Zhuang, Tiantian Wang, Yu Zhang
Format: | Article |
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Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Extra-cytoplasmic function (ECF) σ factors allow bacteria to rapidly respond to stress conditions. Here the authors provide insights into the mechanism of bacterial stress-induced transcription by determining the crystal structures of the M. tuberculosis ECF σ factor bound RNA Polymerase (RNAP) holoenzyme and the ECF σ factor-RNAP transcription initiation complex.