Structural basis for transcription initiation by bacterial ECF σ factors

oleh: Lingting Li, Chengli Fang, Ningning Zhuang, Tiantian Wang, Yu Zhang

Format: Article
Diterbitkan: Nature Portfolio 2019-03-01

Deskripsi

Extra-cytoplasmic function (ECF) σ factors allow bacteria to rapidly respond to stress conditions. Here the authors provide insights into the mechanism of bacterial stress-induced transcription by determining the crystal structures of the M. tuberculosis ECF σ factor bound RNA Polymerase (RNAP) holoenzyme and the ECF σ factor-RNAP transcription initiation complex.