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Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization
oleh: Ting Wu, Zhiqiang Pan, Chengfeng Xia
Format: | Article |
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Diterbitkan: | SpringerOpen 2017-05-01 |
Deskripsi
Abstract A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3′-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under mild conditions. Graphical Abstract