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This article proposes a Thomistic account of graced human nature that emphasizes the importance of underlying developments in Aquinas’ doctrine of creation that inform his approach to the doctrine of grace. While post-Cartesian accounts of the human person often reduce the complex causal structure that marks the relationship between God and the human person in Aquinas’ pre-modern theological anthropology, this article recovers a more comprehensive account of Aquinas’ account of human sanctification and divine causality. Where modern and postmodern anthropologies are often marked by scientific determinism or subjectivism, Aquinas’s anthropology of grace refuses the modern dichotomization of immanence and transcendence, proposing instead an understanding of grace as the divinization of the human person as image of God that is marked not only by the supernatural finality of beatitude, but the intrinsic and personal immanence of divine indwelling.