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<i>Hericium erinaceus</i> (<i>H. erinaceus</i>) is a rare and appreciated fungal species belonging to the division <i>Basidiomycota</i> used for centuries in traditional Chinese medicine for its medicinal value. This species of mushrooms brings the most diverse benefits for the human body, and can have beneficial effects for treating Alzheimer’s disease (AD). This study investigated whether ethanolic extract from the fungal biomass of <i>H. erinaceus</i> enhances cognitive function via the action on cholinergic neurons using the scopolamine (SCOP)-induced zebrafish (<i>Danio rerio</i>) model of memory impairment. The ethanolic extract from the fungal biomass of <i>H. erinaceus</i> was previously obtained using an ultrasonic extraction method (UE). The administration of <i>H. erinaceus</i> extract to zebrafish, with a pattern of AD induced by scopolamine, showed an improvement in memory evaluated by behavioral and biochemical tests on brain tissue. These results suggest that <i>H. erinaceus</i> has preventive and therapeutic potentials in managing memory deficits and brain oxidative stress in zebrafish with AD.