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This study reports the immunotherapeutic effects of Aloe (A.) vera polysaccharides against coccidiosis in broiler chicken. For the purpose, polysaccharides were recovered from A. vera and analyzed by using HPLC. Three different hexose sugars including maltose, glucose and mannose were detected in hydrolyzed solution of A. vera. The extracted polysaccharides (graded doses) were evaluated for immunotherapeutic activities against coccidiosis in chicken. Results revealed that percent protection and daily weight gains were significantly higher (P<0.05) in chicken administered with A. vera polysaccharides as compared to control group. On the other hand, oocyst counts and lesion scores were lower (P<0.05) in polysaccharides administered chickens as compared to control. Moreover, anti-coccidial indices were also higher in chickens administered with polysaccharides (159.75-239.63) as compared to control (36.57). Except spleen, the organ-body weight ratios of all lymphoid organs of experimental and control groups were statistically similar (P>0.05). Based upon findings of this study, it was concluded that A. vera derived polysaccharides had immunotherapeutic activity against coccidiosis in chickens and might be further explored for its commercial feasibility for effective use in poultry industry to control avian coccidiosis.