The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice
по: Jing Wu, Dandan Bu, Haiquan Wang, Di Shen, Danyang Chong, Tongyu Zhang, Weiwei Tao, Mengfei Zhao, Yue Zhao, Lei Fang, Peng Li, Bin Xue, Chao-Jun Li
| Формат: | Article |
|---|---|
| Опубликовано: | Nature Portfolio 2023-03-01 |
Описание
Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver of male mice, and that deletion of Egr-1 results in increased liver fat accumulation.