Improved measures for evolutionary conservation that exploit taxonomy distances
oleh: Nawar Malhis, Steven J. M. Jones, Jörg Gsponer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Information on protein sequence variability and conservation can be leveraged to identify functionally important regions. Here, the authors develop new conservation measures that exploit taxonomy distances and LIST, a tool for predicting deleteriousness of human variants.