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Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study

oleh: Marjon H Cnossen, Frank W G Leebeek, Ron A A Mathôt, M Coppens, MJHA Kruip, S Polinder, K Fischer, R Liesner, K Fijnvandraat, Laura H Bukkems, PW Collins, P Chowdary, K Meijer, A Janssen, MH Cnossen, Jessica M Heijdra, Wala Al Arashi, Nico C B de Jager, Michael E Cloesmeijer, Christian M Zwaan, FWG Leebeek, RAA Mathôt, RYJ Tamminga, BAP Laros-van Gorkom, P Brons, SEM Schols, FJM van der Meer, HCJ Eikenboom, REG Schutgens, F Heubel-Moenen, L Nieuwenhuizen, P Ypma, MHE Driessens, CM Zwaan, I van Vliet, D Keeling, J Lock, HCAM Hazendonk, I van Moort, T Preijers, JM Heijdra, NCB de Jager, MCHJ Goedhart, LH Bukkems, W Al Arashi, ME Cloesmeijer