Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
oleh: Feixiang Yuan, Haizhou Jiang, Hanrui Yin, Xiaoxue Jiang, Fuxin Jiao, Shanghai Chen, Hao Ying, Yan Chen, Qiwei Zhai, Feifan Guo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
The browning of white adipose tissue has potential benefits on metabolic disorders, but the nutritional factors and neuronal signals that mediate browning remain incompletely understood. Here, the authors show that leucine deprivation can induce WAT browning via GCN2/ATF4 signaling in amygdalar PKC-δ neurons.