Chevalones H–M: Six New α-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus <i>Aspergillus hiratsukae</i> SCSIO 7S2001

oleh: Xia-Yu Chen, Qi Zeng, Yu-Chan Chen, Wei-Mao Zhong, Yao Xiang, Jun-Feng Wang, Xue-Feng Shi, Wei-Min Zhang, Si Zhang, Fa-Zuo Wang

Format: Article
Diterbitkan: MDPI AG 2022-01-01

Deskripsi

Six new α-pyrone meroterpenoid chevalones H–M (<b>1</b>–<b>6</b>), together with six known compounds (<b>7</b>–<b>12</b>), were isolated from the gorgonian coral-derived fungus <i>Aspergillus hiratsukae</i> SCSIO 7S2001 collected from Mischief Reef in the South China Sea. Their structures, including absolute configurations, were elucidated on the basis of spectroscopic analysis and X-ray diffraction data. Compounds <b>1</b>–<b>5</b> and <b>7</b> showed different degrees of antibacterial activity with MIC values of 6.25–100 μg/mL. Compound <b>8</b> exhibited potent cytotoxicity against SF-268, MCF-7, and A549 cell lines with IC<sub>50</sub> values of 12.75, 9.29, and 20.11 μM, respectively.