Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
oleh: Weiwei Zhu, Xiang Zhen, Jingyuan Wu, Yaping Cheng, Junkai An, Xingyu Ma, Jikun Liu, Yuji Qin, Hao Zhu, Jijun Xue, Xianxing Jiang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF3Et2O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF3·Et2O as the fluorine reagent in the presence of chiral iodine catalyst.