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We described a rare case of a splenic infarction associated with typhoid fever in a 26-year-old Bangladeshi man who returned from a vacation 10 days ago from his home country and presented to the emergency department with fever followed by left hypochondrial pain. Contrast-enhanced computed tomography of the abdomen showed multiple areas of splenic infarction. Salmonella typhi, which was sensitive to ceftriaxone, grew in the blood culture. The patient received intravenous ceftriaxone, analgesics, hydration, antiemetics, and other supportive care. He showed significant clinical improvement and was discharged. The patient was seen at the hospital two months after discharge, he was doing well and no splenic infarction could be detected by sonography.