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Objective: To analyze the clinical spectrum of skin conditions in neonates at Hamdard university hospital. Study Design: Descriptive (Observational) cross sectional study.Methods: This study was conducted from January 2008 to December 2009. All neonates seen at Hamdard university hospital during this period were examined. Neonates with skin conditions with in 28 days of birth were registered on a predesigned questioner by the house officer these cases were confirmed by the pediatric consultant, followed by detail physical systemic examination and skin examination. Dermatologist was involved in the diagnosis of difficult cases.Results: Total numbers of new born seen during the year 2008- 2009 were 1660, there were 65% males and 35% females, 1360 (81.92%) were above 2.5 Kg at birth, 18.08% were below 2.5 Kg. Numbers of neonates with skin lesions were 577 (34.75%). Neonates with skin infections were 25.12%, 15.59% had with nappy rash and 15.59 % had erythema toxicum neonatrum. Neonates with milia were 60 (10.39%) and with erythema were 27 (4.67%).Conclusion: Clinical spectrums of neonatal skin are different in this study as compared to other regional and international studies.