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Treatment of long-acting, anticoagulant rodenticides (LAAR)-poisoned patients with high-dose oral vitamin K1 (VK1) is expensive and requires several months. The long duration can result in non-adherence leading to recurrent severe coagulopathy, bleeding, and hospitalizations. Cholestyramine (CSA) is an inexpensive, safe, and effective gut-restricted resin used to treat primary hypercholesterolemia or pruritus, and to accelerate clearance of teriflunomide. We propose using inexpensive CSA therapy in LAAR-poisoned patients while administering daily high-dose oral VK1 and periodically monitoring plasma LAAR concentrations until declining to a safe concentration. We suggest that this regimen should be available to public health clinics responding to outbreaks of LAAR poisoning. CSA treatment could improve patient adherence, shorten duration of high dose oral VK1 therapy, and reduce healthcare expenditures.