Novel Coumarin–Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’s Disease
oleh: Elaheh Babaei, Tuba Tüylü Küçükkılınç, Leili Jalili-Baleh, Hamid Nadri, Esin Öz, Hamid Forootanfar, Elaheh Hosseinzadeh, Tayebeh Akbari, Mehdi Shafiee Ardestani, Loghman Firoozpour, Alireza Foroumadi, Mohammad Sharifzadeh, Bi Bi Fatemeh Mirjalili, Mehdi Khoobi, Mehdi Khoobi
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2022-06-01 |
Deskripsi
Graphical AbstractA novel series of 3-phenyl-coumarin derivatives containing pyridinium salts was prepared, indicating significant inhibitory activity against AChE and BuChE as well as precious neuroprotective and anti-Aβ aggregation effects.