Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
oleh: Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov, Baoji Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.