Regio- and enantioselective remote hydroarylation using a ligand-relay strategy
oleh: Yuli He, Jiawei Ma, Huayue Song, Yao Zhang, Yong Liang, You Wang, Shaolin Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Migratory alkene isomerizations and cross-coupling reactions are both possible under nickel catalysis, but usually require different conditions. Here the authors show a combined protocol to isomerize a double bond and then, via an in-situ exchange of ligands, perform an enantioselective C(sp2)–C(sp3) cross-coupling.