Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities
oleh: Mariana F. do C. Cardoso, Ana T. P. C. Gomes, Caroline dos S. Moreira, Mário M. Q. Simões, Maria G. P. M. S. Neves, David R. da Rocha, Fernando de C. da Silva, Catarina Moreirinha, Adelaide Almeida, Vitor F. Ferreira, José A. S. Cavaleiro
| Format: | Article |
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| Diterbitkan: | MDPI AG 2017-02-01 |
Deskripsi
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4b–g and of the sulfonyl-lapachones 7e and 7g reduced the growth of S. aureus.