Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride
oleh: Balladka Kunhanna Sarojini, Badiadka Narayana, Seranthimata Samshuddin, Rajagopalan Srinivasan
Format: | Article |
---|---|
Diterbitkan: | MDPI AG 2012-08-01 |
Deskripsi
A novel route for the synthesis of new spirocyclic derivative is developed. The present work involves the synthesis of title compound <strong>3</strong> by Suzuki coupling of 3,5-difluorophenyl boronic acid with <em>tert</em>-butyl 1-(5-bromofuran-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate (<strong>2</strong>), which in turn prepared from the ethyl nipecotate (<strong>1</strong>). Newly prepared spirocyclic derivative (<strong>3</strong>) is characterized by IR, NMR and mass spectral data.