Impact of Exercise Modalities on Peripheral and Central Components of Cardiorespiratory Capacity in Heart Transplantation Patients: A Systematic Review and Meta-Analysis

oleh: Natália Turri-Silva, Francisco Valdez Santos, Wanessa Camilly Caldas Rodrigues, Josuelir Silva Freire, Lawrence C. Cahalin, Kenneth Verboven, João Luiz Quaglioti Durigan, Dominique Hansen, Gerson Cipriano

Format: Article
Diterbitkan: MDPI AG 2021-12-01

Deskripsi

<i>Background and Objectives:</i> To analyze the effects of aerobic, resistance, and combined training on peripheral and central components related to cardiorespiratory capacity after HTx. <i>Materials and Methods</i>: No time restriction was applied for study inclusion. MEDLINE/PubMed; EMBASE, CENTRAL, and PEDro databases were investigated. Studies reporting heart transplanted patients older than 19 years following aerobic, resistance, and combined training according. The outcomes included: V′O<sub>2</sub> peak, VE/V’CO<sub>2</sub> slope, heart rate (HR peak), systolic and diastolic blood pressure (SBP and DBP peak), maximum repetition test(1RM), sit-to-stand test, and flow-mediated dilation (FMD). The studies were selected by consensus. Four hundred ninety-two studies initially met the selection criteria. Cochrane handbook was used for abstracting data and assessing data quality and validity. Independent extraction by two observers was applied. <i>Results</i>: Isolated aerobic training leads to a greater increase in V′O<sub>2</sub> peak than combined training compared to the control group (<i>p</i> < 0.001, I2 = 0%). However, no significant differences were found in the subgroup comparison (<i>p</i> = 0.19, I2 = 42.1%). HR peak increased similarly after aerobic and combined training. High-intensity interval training (HIIT) was better than moderate continuous intensity to increase the V′O<sub>2</sub> after long term in HTx. Still, there is scarce evidence of HIIT on muscle strength and FMD. No change on VE/V’CO<sub>2</sub> slope, FMD, and SBP, DBP peak. 1RM and the sit-to-stand test increased after resistance training (<i>p</i> < 0.001, I2 = 70%) and CT (<i>p</i> < 0.001, I2 = 0%) when compared to control. <i>Conclusions</i>: Aerobic and combined training effectively improve VO<sub>2</sub> peak and muscle strength, respectively. HIIT seems the better choice for cardiorespiratory capacity improvements. More studies are needed to examine the impact of training modalities on VE/V’CO<sub>2</sub> slope and FMD.