Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
oleh: Ahmed A. Quadeer, John P. Barton, Arup K. Chakraborty, Matthew R. McKay
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Poliovirus has a higher mutation rate than HIV, yet has been almost eradicated by vaccination while an effective vaccine against HIV does not exist. Here, the authors develop a fitness model for poliovirus viral protein 1 to show that it is subject to stringent evolutionary constraints that limit its ability to avoid vaccine-induced immune responses.