Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
oleh: Patrick K. Tumwebaze, Melissa D. Conrad, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Jennifer Legac, Shreeya Garg, David Giesbrecht, Sawyer R. Smith, Frida G. Ceja, Samuel L. Nsobya, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have emerged, compared to eastern Uganda.