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Insulin resistance is linked to a specific profile of immune activation in human subjects
oleh: Renaud Cezar, Delphine Desigaud, Manuela Pastore, Lucy Kundura, Anne-Marie Dupuy, Chantal Cognot, Thierry Vincent, Christelle Reynes, Robert Sabatier, Elisabeth Maggia, Pierre Corbeau
Format: | Article |
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Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Abstract We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. One of these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, and endothelial activation, presented elevated insulinemia, glycemia, triglyceridemia, and γ-glutamyl transferase, a marker of liver injury, in comparison with other profiles. Our data are compatible with a model in which a particular immune activation profile might favor the development of insulin resistance and metabolic syndrome. In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis.