Site-specific ubiquitylation acts as a regulator of linker histone H1
oleh: Eva Höllmüller, Simon Geigges, Marie L. Niedermeier, Kai-Michael Kammer, Simon M. Kienle, Daniel Rösner, Martin Scheffner, Andreas Marx, Florian Stengel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
While the role of specific posttranslational modifications (PTMs) is increasingly well understood for core histones, this is not the case for linker histone H1. Here the authors show that site-specific ubiquitylation of H1 results in distinct interactomes, regulates phase separation, and modulates assembly of chromatosomes.