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Introduction:Gestational diabetes mellitus (GDM) presents major health concerns due to its unfavorable impact on pregnancy outcomes and it has no established predictive test. The objective of this research is to determine out the value of triple test analytes and second-trimester uterine artery (UtA) Doppler analysis together in the estimation of GDM.Methods:In this retrospective study, the clinical data of 87 women with GDM and 723 women with normal glucose tolerance (NGT) were compared. Maternal triple test analytes [human chorionic gonadotropin (hCG), estriol, and alpha-fetoprotein (AFP)] as multiples of the median values and second-trimester UtA Doppler examination for the presence or absence of notching, the left and right UtA pulsatility index (PI), and mean UtA PI was recorded for the NGT and GDM groups.Results:In terms of maternal serum hCG, estriol, and AFP, the study groups were found as similar. The presence of UtA notching was considerably higher in the women who developed GDM. The mean UtA PI provided good diagnostic accuracy for predicting GDM with an optimal cut-off point of >1,195 with a sensitivity of 66.7% and a specificity of 77.3%. Multivariate logistic regression revealed that the presence of a history of GDM and bilateral UtA notching was found to be a predictor of the development of GDM.Conclusion:Second-trimester UtA Doppler ultrasonography but not the triple test analytes has a place for predicting GDM in some pregnant populations, especially in women for whom GDM screening cannot be carried out because of the hesitancy of the oral glucose tolerance test.