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The main aim of orthodontic treatment is to achieve most stable, functional, and esthetic outcome either by conventional, interdisciplinary, or surgical protocol. Treatment modalities differ for growing and nongrowing patients. In nongrowing patients with moderate to severe dental and skeletal deformities, interdisciplinary treatment combined approach is required with orthodontics and orthognathic surgery. Case discussed here is of class III skeletal bases with orthognathic maxilla and prognathic mandible having anterior crossbite with a horizontal growth pattern treated by transdisciplinary approach with combination of orthodontics, orthognathic surgery, and prosthetic approach to get best achievable results of skeletal class III malocclusion.