Serum Endostatin Levels in Oral Squamous Cell Carcinoma
oleh: Maryam Mardani, Azadeh Andisheh-Tadbir, Mohammad Ali Ranjbar, Bijan Khademi, Mohammad Javad Fattahi, Ahmad Rahbar
| Format: | Article |
|---|---|
| Diterbitkan: | Mashhad University of Medical Sciences 2018-05-01 |
Deskripsi
Introduction: Endostatin is a C-terminal proteolytic fragment of collagen XVIII and, as with angiostatin and thrombospondin, is known as an antiangiogenic agent. The aim of this study was to assess the level of serum endostatin in patients with oral squamous cell carcinoma (SCC), and its association with the clinicopathological characteristics of the tumor. Materials and Methods: Using an enzyme-linked immunosorbent assay (ELISA) kit, we investigated the circulating levels of endostatin in the blood serum of 45 patients with oral SCC and 45 healthy controls. Results: The mean level of serum endostatin in patients was significantly lower (68.8±85 ng/ml) than in healthy controls (175.6±73 ng/ml) (P