Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
oleh: Guohao Wang, Junji Xu, Jiangsha Zhao, Weiqin Yin, Dayong Liu, WanJun Chen, Steven X. Hou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Cancer stem cells (CSC) have been shown as the origin for therapeutic resistance and patient relapse. Here, the authors show that targeting Arf1-mediated lipid metabolism in CSC induces cell death but also an immunogenic anti-cancer response.