PHYSICAL-CHEMICAL PRINCIPLES OF THE PREPARATION OF HYBRID MATERIALS ON THE BASIS OF DETONATION NANODIAMONDS AS A NEW GENERATION DRUG DELIVERY SYSTEMS AND THEIR PROPERTIES
oleh: R. Y. Yakovlev, I. I. Kulakova, G. A. Badun, G. V. Lisichkin, A. V. Valueva, N. G. Selezenev, N. B. Leonidov
| Format: | Article |
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| Diterbitkan: | LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01 |
Deskripsi
There were illustrated the main questions of development of new generation drug delivery systems as hybrid nanomaterials as follows: selection of nanocarrier, its standardization and the methods of immobilization of biologically active and medicinal substances. The basic organs of distribution and accumulation of advanced carbon nanocarrier - detonation nanodiamond were identified. It was shown that antihypoxic effect of the nanodiamond-glycine conjugate increased in comparison with a native Glycine and Mexidolum® as reference drugs.