Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
oleh: Jana Balounová, Iva Šplíchalová, Martina Dobešová, Michal Kolář, Karel Fišer, Jan Procházka, Radislav Sedlacek, Andrea Jurisicova, Hoon-ki Sung, Vladimír Kořínek, Meritxell Alberich-Jorda, Isabelle Godin, Dominik Filipp
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2019-11-01 |
Deskripsi
There is limited knowledge of markers to identify various waves of murine embryonic hematopoiesis. Here, the authors show that the expression of toll-like receptor 2 (TLR2) on E7.5 c-kit+ cells marks the emergence of erythro-myeloid progenitor precursors and that the Tlr2 locus is active in E8.5 precursors of adult HSCs.