Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
oleh: Yiting Luo, Zhiwei Meng, Huanan Hu, Liangfu Song, Qianqian Fang, Junjun Zheng
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2011-02-01 |
Deskripsi
A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.